SERUM TRANSAMINASES AND ISOCITRIC DEHYDROGENASE IN KWASHIORKOR

Serum transaminases and isocitric dehydrogenase in kwashiorkor.

Serum glutamic oxalacetic transaminase (G-OT), glutamic-pyruvic transaminase (G-PT), and isocitric dehydrogenase (ICD) have been estimated in six groups of subjects, namely, normal British adults, normal Nigerian adults, undernourished Nigerian adults and children, Nigerian children with florid protein malnutrition (kwashiorkor), and cases of protein malnutrition after treatment. The normal ran...

Serum siderophilin in kwashiorkor.

Kwashiorkor is known to be associated with low plasma proteins (Edozien, 1960) and low serum ironbinding capacity (Edozien and Udeozo, 1960). Unpublished observations of Neale and Soothill (1958) confirmed that the iron-binding capacity was down to about one-third of a normal level, but showed that the siderophilin (syn. transferrin) was much more profoundly depressed-down to 6 mg./ 100 ml., co...

Serum immunoglobulins in kwashiorkor.

Infection and protein calorie malnutrition frequently coexist (Smythe, 1958; Brown, 1965; Phillips and Wharton, 1968), and though it is apparent that infection may affect nutrition adversely, it is difficult to prove that malnutrition is a factor in poor response to infection. In 1965 the World Health Organization Expert Committee on nutrition stated: 'The concept that malnutrition could make m...

Triphosphopyridine nucleotide linked isocitric dehydrogenase in bacteria.

The conversion of isocitric acid to alpha-ketoglutarate has been demonstrated both in animal tissues (Martius, 1937; Krebs and Johnson, 1937; Adler et al., 1939; Ochoa, 1948) and in yeast (Kornberg and Pricer, 1951; Foulkes, 1951). Triphosphopyridine nucleotide was first implicated as a specific coenzyme for this reaction by Adler et al. (1939). Recently Kornberg and Pricer (1951) found in yeas...

Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues.